Effect of nintedanib thermo-sensitive hydrogel on neovascularization in alkali burn rat model
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چکیده
منابع مشابه
Effect of Hydrophobic Pollution on Response of Thermo-Sensitive Hydrogel
Hydrogels are widely studied for chemical sensors. However, they are known to adsorb organic compound and metal ions. The adsorption abilities of hydrogels against organic compounds and metal ions will negatively affect the performance of a hydrogel based chemical sensor. To clarify the effect of hydrophobic pollution on swelling behavior of temperature-sensitive gel, the temperature-responses ...
متن کاملInhibitory effect of polysulfated heparin endostatin on alkali burn induced corneal neovascularization in rabbits.
AIM To investigate anti-angiogenic effects of polysulfated heparin endostatin (PSH-ES) on alkali burn induced corneal neovascularization (NV) in rabbits. METHODS An alkali burn was made on rabbit corneas to induce corneal NV in the right eye of 24 rabbits. One day after burn creation, a 0.2 mL subconjunctival injection of 50 µg/mL PSH-ES, 50 µg/mL recombinant endostatin (ES), or normal saline...
متن کاملMinocycline Inhibits Alkali Burn-Induced Corneal Neovascularization in Mice
The purpose of this study was to investigate the effects of minocycline on alkali burn-induced corneal neovascularization (CNV). A total of 105 mice treated with alkali burns were randomly divided into three groups to receive intraperitoneal injections of either phosphate buffered saline (PBS) or minocycline twice a day (60 mg/kg or 30 mg/kg) for 14 consecutive days. The area of CNV and corneal...
متن کاملThalidomide prevents donor corneal graft neovascularization in an alkali burn model of corneal angiogenesis.
OBJECTIVE Thalidomide is a potent inhibitor of angiogenesis. We evaluated the effects of Thalidomide on corneal angiogenesis and on tissue survival of grafts in rabbit eyes with pre-existing neovascularization secondary to alkali burn. METHODS Sixteen rabbits received alkali burns to one cornea. One month post-injury, assessments of corneal neovascularization were performed followed by cornea...
متن کاملPlasminogen kringle 5 inhibits alkali-burn-induced corneal neovascularization.
PURPOSE Plasminogen kringle 5 (K5) is a potent angiogenic inhibitor. The purpose of the present study was to evaluate the therapeutic effect of K5 on alkali-burn-induced corneal neovascularization (NV) and to investigate its mechanism of action. METHODS Corneal NV was induced in rabbits by NaOH. The rabbits received eye drops containing K5 or vehicle alone, four times per day. Corneal NV and ...
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ژورنال
عنوان ژورنال: International Journal of Ophthalmology
سال: 2020
ISSN: 2222-3959,2227-4898
DOI: 10.18240/ijo.2020.06.04